Results: Shift workers had significantly higher levels of serum triglyceride (1.26 versus 1.03 mmol/L, p = 0.01). Main outcome measures: Fasting venous plasma concentration of total cholesterol, triglyceride, and high-density lipoprotein (HDL) cholesterol dietary intake assessed by a 3-day record, smoking habits, and body mass index (BMI). Day workers matched with shift workers according to age, educational level, birthplace, and occupational physical activity level served as controls 109 were selected, 26 were excluded or absent, and 10 refused to participate. One hundred nine persons were selected, 25 were excluded or absent during the study, and 11 refused to participate. Participants: All the shift workers of the chemical plant and of one part of the nuclear station. Setting: Two plants of northern France: a chemical one and a nuclear power station. Purpose: To assess an independent relationship between shift work and serum lipid levels. These interesting findings emphasize the beneficial effect on atherosclerotic risk markers of dietary n-6 polyunsaturated and monounsaturated fatty acids, and suggest that long-chain n-3 polyunsaturated fatty acids (DHA) could have an adverse effect on some of the lipid risk markers. 001) the latter showed a negative association with stearic acid ( P <. There was a negative association between palmitoleic acid and apo B ( P <. 05), while arachidonate showed an inverse relationship with plasma cholesterol level ( P <. On the other hand, phospholipid α-linolenate was positively correlated with apo A-I and high-density lipoprotein (HDL) cholesterol levels ( P <. 05) recognized by a monoclonal antibody (LpB元). 05), and apo B-containing lipoprotein particles ( P <. 01), low-density lipoprotein (LDL) cholesterol ( P <. There was a surprisingly significant positive association between the docosahexaenoic acid ( 22:6n-3) content of erythrocyte phospholipids and the following risk markers: plasma cholesterol ( P <. This study examined the relationship between the fatty acid composition of red blood cell phospholipids and lipid markers of atherosclerotic risk in an urban male population aged 45 to 66 years. These results confirm LDL abnormalities in hemodialyzed patients and suggest a possible modification of the recognition of the LDL by cells. It is important to consider a structural modification as it alters the B/E receptor recognition domain of apo B. The conformation of patients' LDL (CRF-LDL) was probably abnormal and seemed to be related to some modification of the lipidic environment. The accessibility of BL5 epitopes of LDL apo B was enhanced (P < 0.05), while BA11 epitope expression was decreased (P < 0.01). In hemodialyzed patients, LDL content of triglycerides (P < 0.001) and apo CIII (P < 0.005) was increased, while cholesteryl esters (P < 0.005) were decreased. Mab BA11 recognizes a fragment of apo B which interacts with the B/E receptor. These Mabs recognize fragments on the N-terminal part of apo B (Mabs B1, B4), on the middle part (Mab BL7), on the C-terminal (Mabs BA11, B元), and the two remaining Mabs recognize conformational epitopes of apo B (BL5, DA7). LDL apolipoprotein B (apo B) epitope accessibility was determined by the use of seven monoclonal antibodies (Mabs). Serum and isolated low-density lipoprotein (LDL) composition abnormalities were investigated in 20 hemodialyzed patients with chronic renal failure and 15 healthy normolipidemic subjects for comparison. Expression of apolipoprotein B epitopes in low density lipoproteins of hemodialyzed patients.
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